Study Data
Davis SC, Cazzaniga AL, Ricotti C, et al. Topical oxygen emulsion: a novel wound therapy. Arch
Dermatol.
2007;143(10):1252-1256.
PARTIAL THICKNESS WOUND HEALING
- 8 subjects each received 80 partial thickness wounds 10 x 7 x 0.3 mm deep using an electrokeratome
- SSOE applied twice daily for 5 days and once daily thereafter until complete epithelialization
- By day 6, all (100%) SSOE-treated wounds healed (complete epithelialization) compared to 8% of the control (air-treated wounds)
– Statistically significant (P < 0.001) results are observed for days 3–7
SECOND DEGREE BURNS
-
8 subjects each received 100 burn wounds using a hot cylindrical brass rod - Burns were randomly assigned to treatment with PFD emulsion or exposed to air and untreated
- Burns were treated twice daily with SSOE for 5 days
- 100% of the SSOE-treated burns completely healed by day 10 compared to 25% of the untreated burns
– Burns treated with SSOE demonstrated an up-regulation of collagen I, III, and VEGF production
Collagen Type I, III, and VEGF Expression
-
SSOE topically applied for 5 days after burn is created - Burns treated with SSOE demonstrated an up-regulation of collagen I, III, and VEGF production
- C is non-oxygenated PFD emulsion and D is SSOE